The premise of this sci-fi novel is that, in 2008, a scientific breakthrough allows for genetic engineering that creates people with no need to sleep. Together with other genetic advantages available to the rich, soon this creates a small but growing group of privileged and brilliant young people - the Sleepless. However, jealous and resentful, "ordinary people" rather than appreciating the super-talented Sleepless, are soon viciously prejudiced against them.
I found the first half of this book to be interesting and refreshing, because, although I didn't find the supposed benefits that Kress pairs with sleeplessness to be medically convincing, it was nice to see (for once) a scientific advance that has the ability to change humanity shown in a positive light, rather than as a Scary Mutation of Terror that makes us Inhuman.
However, the second half of the book spoiled all that, when it posits that a large percentage of the Sleepless, sick of the bigotry aimed at them, secede into a gated compound, and proceed to do more genetic research and create Inhuman Mutations and commit Terrible Acts. By taking the idea further, I felt that the novel, conversely, got more ordinary.